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CCL13
ββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββ
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Contents
β’ Eigenschaften
β’ Einzelnachweise
ββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββ
Eigenschaften
CCL8 ist an EntzΓΌndungsprozessen beteiligt. Es ist chemotaktisch fΓΌr und aktiviert verschiedene Immunzellen, darunter Monozyten, Eosinophile, T-Lymphozyten und Basophile durch Bindung an CCR2, CCR3 und CCR5.cite-ref-1[1] CCL13 ist an der Entstehung von Asthma beteiligt.cite-ref-2[2] CCL13 wird durch die Zytokine Interleukin-1 und TNF-Ξ± induziert.
Einzelnachweise
cite-note-11. β Blanpain et al., CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist. Blood. 1999, 94:1899-905.
cite-note-22. β Lamkhioued et al., Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory cytokines. Am J Respir Crit Care Med. 2000, 162:723-32.